Three factors influence the occurrence of thrombosis: blood stasis, endothelial injury and thrombophilia (The Virchow triangle). Thrombophilia is an inherited or acquired predisposition, detected by a set of laboratory tests, which increases the risk for venous thromboembolism (DVT or PE) or pregnancy complications, like: preeclampsia, intra-uterine fetal death, intra-uterine growth restriction and placental abruption [1,2]. Acquired or secondary thrombophilia includes: active cancer, certain chemotherapies, nephrotic syndrome, disseminated intravascular coagulation (DIC), thrombosis thrombocytopenic purisra (TTP), pregnancy and some inflammatory or autoimmune diseases.
The pain initially felt like it was coming from my calf, then behind my knee, and as time passed it seemed to travel down my leg. In my ignorance, I thought the pain was working itself down and out, so it must be improving.
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